That's a one hit kill and I have perk that gives me extra AP for killing bad guys in VATS so once the initial two are dead, I still have close to a fool AP bar to play around with any enemies who aren't dead yet. Most of my battles start off with me sneak critical killing two bad guys before they're aware of anything. The build worked well enough for me in FO3 but I've got it down packed from the get go in NV and it's really smooth. I've got a thing for pistols in any game that lets me carry a gun, so I completely ignore explosives, energy weapons and any other skill that boosts a weapon other than guns.
I don't grasp the concept of playing this and F03 in melee so I completely ignore everything relating to unarmed or hand-to-hand combat. My build is similar to yours but rather than make strength high I went for perception.
Said: ' SPECIAL put most into agility, strength and intelligence Skills sneak, melee/unarmed (which one is generally better?), guns, science, speech.